The TiNOX Trial: Randomized comparison of titanium nitride oxide coated stents with bare metal stents: A five year follow-up

The TiNOX Trial is a randomized controlled trial comparing bioactive titanium nitride oxide coated stent with bare metal stent of similar identical design with a follow up up to 5 years. 

Study Design:

  • Multi-center, international, prospective, randomized, controlled trial 
  • 5 sites
  • 92 patients
  • Primary Endpoint: MACE at 6 months and 5 years

Key Findings :

MACE rate at 6 months was significantly lower in the bioactive stent arm 7% versus 27% p=0.02 and 16% versus 39% p=0.03 at 5 years demonstrating a sustained efficacy at long term follow up for the bioactive stent versus bare metal stent. Clinical restenosis was significantly lower for the bioactive stent with 7% versus 23% (p=NS) and 9% versus 25% (p=NS) respectively at 6 months and 5 years.