Our Mission

Myocardial infarction was usually known as acute events mainly caused by a blockage preventing blood from flowing to the heart and in this case the most common reason for this is a build-up of fatty deposits on the inner walls of the blood vessels that supply the heart.

Hexacath has targeted this disease developing a unique coronary stent TiTAN OPTIMAX based on a bioactive coating material known as titanium nitride oxide able to reduce both thrombosis and restenosis capable to promote healing post stenting and reducing therefore the need for prolonged Dual Anti Platelet Treament (1, 2, 3, 4, 5, 6, 7, 8, 9).

In addition, physicians have also discovered that up to 50% of patients with chest pain visiting catheterization laboratories do not present with significant epicardial stenosis meaning this dreadful pathology is caused by something else beyond coronary arteries known as the interventional cardiology “Black Box” or Coronary Microcirculation Dysfunction (10, 11).

It took nearly 10 years to Hexacath to develop and patent the RayFlow microcatheter the Key to understand and treat coronary microcirculation dysfunction known as ANOCA (Angina with non obstructive Coronary Arteries) or MINOCA (Myocardial Infarction with Non Obstructive Coronary Arteries).      

  1. 1. Karjalainen P P., et al. Long-term clinical outcome of titanium-nitride-oxide-coated stents versus everolimus-eluting stents in acute coronary syndrome: Final report of the BASE ACS trial. International Journal of Cardiology. 2016; 222: 275–280
  2. 2. Sia J, et al. 10-year follow-up of patients with titanium-nitride-oxide-coated stents versus everolimus-eluting stents in acute coronary syndrome. Cardiovascular Revascularization Medicine. 2025; 80: 101-107
  3. 3. Tonino P A.L., et al, Titanium-Nitride-Oxide–Coated Versus Everolimus-Eluting Stents in Acute Coronary Syndrome: The Randomized TIDES-ACS Trial. JACC: Cardiovascular Interventions. 2020; 80(14): 1697-1705
  4. 4. Bouisset F, et al. Titanium-Nitride-Oxide–Coated vs Everolimus-Eluting Stents in Acute Coronary Syndrome: 5-Year Clinical Outcomes of the TIDES-ACS Randomized Clinical Trial. JAMA Cardiol. 2023;8(7):703–708.
  5. 5. Moschovitis A, et al. Randomised comparison of titanium-nitride-oxide coated stents with bare metal stents: five year follow-up of the TiNOX trial. EuroIntervention. 2010;6(1):63-68.
  6. 6. Windecker S, et al. Randomized comparison of a titanium-nitride-oxide-coated stent with a stainless steel stent for coronary revascularization: the TiNOX trial. Circulation. 2005;111(20):2617-2622.
  7. 7. Windecker S, et al. Stent coating with titanium-nitride-oxide for reduction of neointimal hyperplasia. Circulation. 2001; 104: 928–933.
  8. 8. Steinemann S.G. Metal implants and surface reactions. Injury. 1996; 27(3): S/C16-S/C22
  9. 9. Williams DF. Titanium as a metal for implantation. Part 1: physical properties. J Med Eng Technol. 1977;1(4): 195-198
  10. 10. Patel MR, et al. Low diagnostic yield of elective coronary angiography. N Engl J Med. 2010;362(10):886-895.
  11. 11. Keulards DCJ, et al. Safety of absolute coronary flow and microvascular resistance measurements by thermodilution. EuroIntervention. 2021;17(3):229-232.